Christopher F. Cuff, PhD

Professor Emeritus

Organization:

West Virginia University School of Medicine

Department:

Microbiology, Immunology & Cell Biology

Classification:

Faculty

• PhD, Temple University, 1988

Peer Reviewed Papers

Fulton, J.R. C. Cunningham, J. Smith, and C. F. Cuff. 2003. Analysis of T-cell receptor repertoires expressed by cytotoxic T cells following oral and systemic infection. J. Virol. 78:1592-1590

Mathers, A. and C. F. Cuff. 2003. Roles of interleukin 4 and interleukin 10 on route of infection-dependent IgG subclass responses to reovirus infection. J. Virol. 78:3352-3360

Fulton, J.R. and C. F. Cuff. 2004. Mucosal immunity to reovirus infection in aged mice. Exp. Gerontol. 39:1285-1294.

Pal, K., Kaetzel, C., Brundage, K., Cunningham, C., and C. F. Cuff. 2005 Up-regulation of polymeric immunoglobulin receptor expression by reovirus. J. Gen Virol. 86: 2347-57.

Li, M., C.F. Cuff, and J. Pestka. 2005. Modulation of murine host response to enteric reovirus infection by the trichothecene deoxynivalenol. Tox. Sci. 87:134-145.

Fecek,R.J., Busch,R., Lin,H., Pal,K., Cunningham,C.A., and Cuff,C.F. 2006. Production of Alexa Fluor 488-labeled reovirus and characterization of target cell binding, competence, and immunogenicity of labeled virions. J Immunol Methods. 30-37.

Li M, Cuff C.F., Pestka JJ. 2006. T-2 toxin impairment of enteric reovirus clearance in the mouse associated with suppressed immunoglobulin and IFN-gamma responses. Toxicol Appl Pharmacol. 214:318-325.

Li,M., Harkema,J.R., Islam,Z., Cuff, C.F., and Pestka,J.J. 2006. T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis. Toxicol.Applied Pharmacol. 217:76-85.

Li,M., Harkema,J.R., Cuff, C.F., and Pestka,J.J. 2007. Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection. Tox Sci. 95(2):412-26.

Zhao J, Li QQ, Zou B, Wang G, Li X, Kim JE, Cuff CF, Huang L, Reed E, Gardner K. In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma. Int J Oncol. 2007 Aug;31(2):241-52.PMID:

Li QQ, Wang G, Zhang M, Cuff CF, Huang L, Reed E. beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis. Oncol Rep. 2009 Jul;22(1):161-70.PMID: 19513519

Li QQ, Wang G, Reed E, Huang L, Cuff CF. Evaluation of Cisplatin in Combination with beta-Elemene as a Regimen for Prostate Cancer Chemotherapy. Basic Clin Pharmacol Toxicol. 2010 Apr 23. [Epub ahead of print]PMID: 20456328

Fecek RJ, Marcondes Rezende M, Busch R, Hassing I, Pieters R, Cuff CF. Enteric reovirus infection stimulates peanut-specific IgG2a responses in a mouse food allergy model. Immunobiology. 2010 Mar 4. [Epub ahead of print]PMID: 20356650

Maddox JF, Amuzie CJ, Li M, Newport SW, Sparkenbaugh E, Cuff CF, Pestka JJ, Cantor GH, Roth RA, Ganey PE.Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity. J Toxicol Environ Health A. 2010;73(1):58-73.PMID: 19953420

Olson JC, Cuff CF, Lukomski S, Lukomska E, Canizales Y, Wu B, Crout RJ, Thomas JG, McNeil DW, Weyant RJ, Marazita ML, Paster BJ, Elliott T. 2011. Use of 16S ribosomal RNA gene analyses to characterize the bacterial signature associated with poor oral health in West Virginia. BMC Oral Health. 2011 Mar 1, 11:7-16. PubMed Central PMCID: PMC3061962.

Cockburn AF, Dehlin J, Ngan T, Crout R, Boskovic G, Denvir J, Primerano D, Plassman B, Wu B and Cuff CF . 2012. High throughput DNA sequencing to detect differences in the subgingival plaque microbiome in elderly subjects with and without dementia. Investigative Genetics. 2012 Sep 21;3(1):19 PMID:22998923

Zou B, Li QQ, Zhao J, Li JM, Cuff CF, Reed E. 2013. β-Elemene and taxanes synergistically induce cytotoxicity and inhibit proliferation in ovarian cancer and other tumor cells. Anticancer Res. Mar;33(3):929-40. PMID:23482764

Li QQ, Wang G, Huang F, Li JM, Cuff CF, Reed E. 2013 Sensitization of lung cancer cells to cisplatin by β-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of β-elemene and its synthetic analogs. Med Oncol. Mar;30(1):488. Epub 2013 Feb 9. PMID: 23397083

Dollive S, Chen Y-Y, Grunberg S, Bittinger K, Hoffmann C, Vandivier, L. Cuff, C, Lewis, J, and Wu, G. (2013) Fungi of the murine gut: episodic variation and proliferation during antibiotic treatment. PLoS ONE 8(8): e71806. doi:10.1371/journal.pone.0071806

Book Chapters

Fulton, J.R. C. A. Cunningham, and C. F. Cuff. 2003. Immunology of the gastrointestinal tract. In Colonic Diseases. T. Koch ed. Humana Press Human Press, Torowa, NJ, pp105-122

Cunningham, C.A., J.R. Fulton, and C.F. Cuff. 2003. Inflammation. In Colonic Diseases. T. Koch ed. Humana Press Human Press, Torowa, NJ, pp 211-222.

Cuff, C.F. and R. Schafer. 2005. Mucosa Associated Lymphoid Tissue. In Encyclopedia of Toxicology, P. Wexler ed. Academic Press, San Diego, CA. pp465-467.

Cuff, C.F. 2006. John Cebra: A Remembrance. Mucosal Immunology Update, 3rd quarter 2006 pp 3-6

View more at PubMed

Academic Interests

Our work primarily deals with studying the cellular and molecular events that result in the development of antigen-specific immune responses in the gastrointestinal tract. These immune responses, mediated largely by IgA antibodies and T-lymphocytes, play an important role in protecting the host against pathogens and toxins that enter the host through the gastrointestinal tract.

Our research program involves the use of murine models of enteric infection as well as human intestinal tissues to analyze the response of the mucosal immune system to stimulation with viruses. The ultimate goals of this work are to understand the pathogenesis of microbes and their toxic products in the gastrointestinal tract, and elucidate mechanisms by which the host protects itself. This work contributes to the development of vaccines and other therapies designed to modulate the immune response, and helps us to develop an understanding of how toxins influence the mucosal immune response.

Non-Programmatically Aligned Cancer Center Members