HanGang Yu, PhD

Associate Professor

Organization:

West Virginia University School of Medicine

Department:

Physiology and Pharmacology

Classification:

Faculty

1. Yu, H. “Depolarization or hyperpolarization: Emerging role of altered bioelectricity in breast cancer metastasis”. eBioMedicine. 2022;76:103853. 

2. Yu, H., Sizemore, G., Smoot, K., & Perrotta, P. (2021). Detecting SARS-CoV-2 Orf3a and E Ion Channel Activity in COVID-19 Blood Samples. Journal of Clinical and Translational Science, 1-18. doi:10.1017/cts.2021.856

3. Hangang Yu, PhD, Bryan Gall, PhD, Mackenzie Newman, PhD, Quincy Hathaway, PhD, Kathleen Brundage, PhD, Amanda Ammer, PhD, Peter Mathers, PhD, David Siderovski, PhD, Robert W. Hull, MD. “Contribution of Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) 1 Variant to Sinus Bradycardia: A Case Report”. Journal of Arrhythmia. Published online (7/13/21). https://doi.org/10.1002/joa3.12598

4. Sizemore, G., McLaughlin, S., Newman, M. Kathleen Brundage, Amanda Ammer, Karen Martin, Elena Pugacheva, James Coad, Malcome D. Mattes, Han-Gang Yu. Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer. BMC Cancer 20, 595 (2020). https://doi.org/10.1186/s12885-020-07071-1
5. Szu-Yuan Wu, Nam-Nhut Phan, Shih-Hsin Ho, Yu-Heng Lai, Tsai chih-hung, Yang Chung-Han, Kuan-Lun Li, Han-Gang Yu, Jung-Chieh Wang, Pung-Ling Huang, Yen-Chang Lin. (2018). Metabolomic Assessment of Arsenite Toxicity and Novel Biomarker Discovery in Early Development of Zebrafish Embryos. Toxicology Letters, 290:116-122.
6. N-N Phan, C-Y Wang, K-L Li, C-F Chen, C-C Chiao, H-G Yu, P-L Huang, Y-C Lin. Distinct Expression of CDCA3, CDCA5, and CDCA8 Leads to Shorter Relapse Free Survival in Breast Cancer Patient. Oncotarget. 2018; 9:6977-6992. https://doi.org/10.18632/oncotarget.24059
7. Zhong P, Vickstrom CR, Liu X, Hu Y, Yu L, Yu HG & Liu QS. (2017). HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress. Elife 6. 2017 Dec 19;6. pii: e32420. doi: 10.7554/eLife.32420. [Epub ahead of print]
8. Newman MS, Nguyen T, Watson MJ, Hull RW & Yu HG. (2017). Transcriptome profiling reveals novel BMI- and sex-specific gene expression signatures for human cardiac hypertrophy. Physiol Genomics 49, 355-367.
9. Hangang Yu, Sarah McLaughlin, Mackenzie Newman, Kathleen Brundage, Amanda Ammer, Karin Martin, James Coad. Altering Calcium Influx for Selective Destruction of Breast Tumor. BMC Cancer (2017) Mar 4;17(1):169. doi: 10.1186/s12885-017-3168-x. PMID: 28259153
10. Seher Berzingi, Mackenzie Newman, Han-Gang Yu. Altering Bioelectricity on Inhibition of Human Breast Cancer Cells. Cancer Cell International, (2016) 16:72. PMCID: PMC5034549
11. Yen-Chang Lin, Jianying Huang, Stan Hileman, Karen Martin, Robert Hull, Mary Davis, Han-Gang Yu (2015). Leptin Decreased Heart Rate Associated with Increased Ventricular Repolarization via Its Receptor. American Journal of Physiology - Heart and Circulatory Physiology, 309, H1731-H1739. PMID: 26408544
12. Jianying Huang, Yen-Chang Lin, Stan Hileman, Karen H. Martin, Robert Hull, Han-Gang Yu. (2014). PP2 prevents beta-adrenergic stimulation of cardiac pacemaker activity. J Cardiovasc Pharmacol 2014; 63(6) 533-43. PMID: 24566462.
13. Yen-Chang Lin, Jianying Huang, Hong Kan, Vince Castronova, Jeffery C. Frisbee, Han-Gang Yu. Defective Calcium Inactivation Causes Long QT in Obese Insulin-Resistant Rat. AJP –Heart & Circulation, 302, H10130-H1022, 2012. PMID: 22198168
14. Han-Gang Yu and Yen-Chang Lin (2011). Future of cardiac pacemaker – an update of biological pacemaker patents. Recent Patents on Biomedical Engineering. 4(1), 6-19.
15. Jian-Ying Huang and Han-Gang Yu. Reduced Tyrosine Phosphorylation Inhibits HCN4-573x Channel Independent of cAMP Signaling. Circulation. 124:A13045, 2011.
16. Han-Gang Yu and Yen-Chang Lin (2011). Biological Pacemaker – Main Ideas and Optimization, in “Modern Pacemakers - Present and Future”, Mithilesh Kumar Das (Ed.), ISBN: 978-953-307-214-2, pp.449-472.
17. Yen-Chang Lin, Jianying Huang, Qi Zhang, John M. Hollander, Jefferson C. Frisbee, Karen H. Martin, Casey Nestor, Robert Goodman, Han-Gang Yu. Inactivation of L-type Calcium Channel modulated by HCN2. AJP-Cell Physiol, 298, C1029-C1037; 2010.
18. Yen-Chang Lin, Jianying Huang, Kan Hong, Jefferson C. Frisbee, Han-Gang Yu. Rescue of a Trafficking Defective Human Pacemaker Channel via a Novel Mechanism: Roles of Src, Fyn, Yes tyrosine kinases. J. Biol. Chem. 284:30433-30440, 2009.
19. Yen-Chang Lin, Jianying Huang, Kan Hong, Jefferson C. Frisbee, Han-Gang Yu. Rescue of a Trafficking Defective Human Pacemaker Channel via a Novel Mechanism: Roles of Src, Fyn, Yes tyrosine kinases. J. Biol. Chem. 284:30433-30440, 2009.
20. Qi Zhang, Aijie Huang, Han-Gang Yu. Associated Changes in HCN2 and HCN4 Transcripts and I(f) Pacemaker Channels in Myocytes. BBA-Biomembrane, 1788:1138-1147, 2009. PMCID: PMC2792982
21. Han-Gang Yu, Racing of Biological Pacemaker, Recent Patents on DNA & Gene Sequences (invited review), 3:193-200, 2009. PMID: 19702558
22. Jianying Huang, Aijie Huang, Qi Zhang, Yen-Chang Lin, and Han-Gang Yu. Novel Mechanism for Suppression of Hyperpolarization-activated Cyclic Nucleotide-gated Pacemaker Channels by Receptor-like Tyrosine Phosphatase-a. J. Biol. Chem.  283: 29912-29919, 2008.
23. Chenhong Li, Qi Zhang, Bunyen Teng, S. Jamal Mustafa, Jianying Huang, and Han-Gang Yu (2008). Src Tyrosine Kinase Alters Gating of Hyperpolarization-Activated HCN4 Pacemaker Channel through Tyr531. Am J Physiol Cell Physiol 294:C355-C362.
24. Xiao Yu; Lijun Yao; Peng Zhou; Ying Li; Hui Zheng; Liang-Hong Zheng; Iain Bruce; Jun-Bo Ge; Shi-Qiang Wang; Han-Gang Yu (co-Corresponding Author ); Zhuan Zhou (2007). Calcium influx through I f channels in rat ventricular myocytes. Am. J. Physiology: Cell Physiol. 292: C1147-C1155, 2007.
25. Arinsburg SS, Cohen IS, Yu HG (2006). Constitutively active Src tyrosine kinase changes gating of HCN4 channels through direct binding to the channel proteins. J. Cardiovascular Pharmacology 2006; 47: 578-586.
26. Yu H, Lu Z, Pan Z, Cohen IS (2004). Tyrosine kinase inhibition differentially regulates heterologously expressed HCN channels. Pflugers Archive 447(4):392-400.
27. Yu X, Duan KL, Shang CF, Yu H, Z. Zhou (2004). Calcium influx through hyperpolarization-activated cation channels (Ih channels) contributes to activity-evoked neuronal secretion. Proc. Nat. Acad. Sci. USA 101(4):1051-1056.
28. Plotnikov AN, Yu H , Geller JC, Gainullin RZ, Chandra P, Patberg KW, Friezema S, Danilo, P, Cohen IS, Feinmark S, Rosen MR. (2003). The role of L-type calcium channels in pacing-induced short-term and long-term cardiac memory in canine heart. Circulation 107:2844-2849.
29. H. Yu , J. Wu, I. Potapova, R.T. Wymore, B.Holmes, J. Zuckerman, Z. Pan, H.Wang, W. Shi, R.. Robinson, M.R. El-Maghrabi, W. Benjamin, J. Dixon, D. McKinnon, I.S. Cohen, and R. Wymore. (2001) MinK-related peptide 1: a beta subunit for the HCN ion channel family, enhances expression and speeds kinetics. Circulation Research 88: e84 - e87.
30. Hangang Yu, Michael R. Rosen, Susan Steinberg, Hong-Sheng Wang, Junyuan Gao, Randy S. Wymore, and Ira, S. Cohen (2000). Effects of the Regin-Angiotensin System on the current ito in epicardial and endocardial ventricular myocytes from the canine heart. Circulation Research 86, 1062-1068. 

Dept. Physiology and Pharmacology

The human heart beats close to 3 billion times in an average lifetime (70 beats/min, 80 years life expectancy). This remarkably reliable biological pump generates the non-stop rhythm due to the concerted interactions among a number of channel and transporter proteins that reside in the plasma membranes of cardiac myocytes. Normal cardiac rhythm relies on the gating of ion channels that controls the firing of action potential which in turn, triggers the muscle contraction. Dysfunction of ion channels (Na⁺, K⁺, Ca²⁺, etc.) will cause irregular heart beat (cardiac arrhythmia), leading to impaired muscle contraction. Ion channels have become new targets for next generation therapeutic treatment of a variety of diseases such as diabetes, heart failure, inflammation, and cancer.

Our research is currently focused on understanding of genetic and molecular mechanisms of two obesity-related cardiac disorders: hypertrophy and cardiac arrest. Due to lack of pharmacological treatment, pathological hypertrophy and cardiac arrest can eventually lead to heart failure and sudden cardiac death, both occurring in a significantly higher rate in obese patients. Additionally, we are also exploring the novel role of altered bioelectricity in the inhibition of human breast tumors.