Paul D Chantler, PhD

Associate Professor

Organization:

West Virginia University School of Medicine

Department:

Human Performance - Exercise Physiology

Classification:

Faculty

Associate Professor

Organization:

West Virginia University School of Medicine

Department:

Department of Neuroscience

Classification:

Faculty

• PhD, Exercise Physiology, Liverpool John Moores University, Liverpool, England, 2004
• BS, Sports Science and Exercise Physiology, Liverpool John Moores University, Liverpool, England, 2001

 

Sample of publications

1. Brooks S, DeVallance, E., d’Audiffret, A., Tabone, L., Shrader, C., Frisbee S, Frisbee, JC., and Chantler, PD. Metabolic syndrome impairs reactivity and wall mechanics of cerebral resistance arteries in obese zucker rats. American Journal of Physiology; Heart and Circulation. 2015, 309(11):H1846-59 PMID:26475592
2. Petrone, AB, O’Connell, GC, Regier, MD, Chantler PD, Simpkins, JW, and Barr, TL. The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity. Translational Stroke Research.  2016 Apr;7(2):103-10.PMID: 26515089
3. Asano S, Chantler PD, and Barr T. Gene expression profiling in stroke: relevance of blood-brain interaction. Current Opinion in Pharmacology. 2016,26:80-86
4. JC Frisbee, JT Butcher, SJ. Frisbee, I.M. Olfert, PD Chantler, LE Tabone, AC d’Audiffret, CD Shrader, AG. Goodwill, PA. Stapleton, SD. Brooks, RW. Brock, and JH Lombard. Increased peripheral vascular disease risk progressively constrains perfusion adaptability in the skeletal muscle microcirculation. 2015. Accepted at American Journal of Physiology; Heart and Circulation. 2016, 310(4):H488-504 Highlighted for AJP: Podcast (2016).
5. DeVallance, E., Fournier SB, Lemaster, K., Moore, C., Lee, K., Donley DA, Bonner DE, and Chantler PD., The Effects of Hypertrophic Resistance Exercise Training on Arterial Stiffness in the Metabolic Syndrome? European Journal of Applied Physiology. 2016 May;116(5):899-910 PMID: 26941024
6. O'Connell G, Petrone A, Treadway M, Tennant C, Lucke-Wold N, Chantler PD, and Barr TL. Machine Learning Approach Identifies a Pattern of Gene Expression in Peripheral Blood Which Can Accurately Detect Ischemic Stroke. Accepted In Press: npj Genomic Medicine
7. Lemaster K, Jackson D, Welsh DG, Brooks SD, Chantler PD, Frisbee JC. Altered distribution of adrenergic constrictor responses contributes to skeletal muscle perfusion abnormalities in metabolic syndrome. In Press. Microcirculation. 2017, 24(2): . PMID: 28036148
8. Chantler PD. Arterial Ventricular Uncoupling with Age and Disease and Recoupling with Exercise. Exerc Sport Sci Rev. 2017 Apr;45(2):70-79 PMID: 28072585.
9. O'Connell G, Treadway M, Petrone A, Tennant C, Lucke-Wold N, Chantler PD, and Barr TL. Peripheral blood AKAP7 expression as a marker for lymphocyte-mediated post-stroke blood brain barrier disruption. Sci Rep. 2017 Apr 26;7(1):1172. PMID:28446746
10. O'Connell GC, Petrone AB, Tennant CS, Lucke-Wold N, Kabbani Y, Tarabishy AR, Chantler PD, and Barr TL. Circulating extracellular DNA levels are acutely elevated in ischaemic stroke and associated with innate immune system activation. Brain Injury. 2017 Jun 6, p1-7
11. O'Connell GC, Treadway M, Petrone AB, Tennant CS, Lucke-Wold N, Chantler PD, and Barr TL. Leukocyte dynamics influence reference gene stability in whole blood: Data-driven qRT-PCR normalization is a robust alternative for measurement of transcriptional biomarkers. In Press. Laboratory Medicine
12. Mathews A, Famodu O, Olfert M, Murray P, Cuff C, Downes M, Haughey N, Colby S, Chantler PD, Olfert IM, and McFadden J. Efficacy of nutritional interventions to lower circulating ceramides in young adults: FRUVEDomic pilot study. Physiological Reports. 2017. Jul 5(13) PMID: 28694327

Biography:

Paul Chantler was born and raised in Liverpool, UK and avid Football (Soccer) player and Athlete, which is where he developed a strong enthusiasm to understand the physiology of exercise. Paul gained his undergraduate and PhD degrees at Liverpool John Moores University, UK. Paul then moved to Baltimore, USA, to the National Institute on Aging, National Institutes of Health, Laboratory of Cardiovascular Science for his Postdoctoral training under the mentorship of Dr. Edward Lakatta and Dr. Samer Najjar.

In 2009, Paul moved to West Virginia University, School of Medicine, Davison of Exercise Physiology where he set up his Human Cardiovascular laboratory in the footprint of the human performance laboratory. To develop a more translational program, Paul also developed his basic skills and now, in addition to the human lab, he runs his vascular biology laboratory on the 3^rd floor of the Health Science Center at WVU. Funding of the years through the AHA, NIH, and foundations has allowed Paul to focus on his important research questions.

Paul has a keen interest in developing young scientists. He has graduated 4 PhD and 5 MS students as the primary mentor. He has a number of undergraduate students rotating and volunteering in his lab, and he is often a summer mentor for the WV INBRE program and the American Physiological Society Summer Research Program.   

Center for Basic and Translational Stroke Research

Research:

My research laboratory has research interests focusing on how the interaction with aging, lifestyle, and various disease states, in particular the Metabolic Syndrome (MetS) and Stroke, impacts cardiac, arterial, and cerebrovascular biology and function. The research goals of my Cardiovascular (CV) Laboratory are to determine:

 

• important changes in CV function with obesity, MetS, Type 2 diabetes and stroke;
• modulation of those changes by biological factors (e.g., elevated lipids, estrogen deficiency) and lifestyle behaviors (e.g., physical activity/inactivity, diet);
• the efficacy of lifestyle/pharmacological interventions for reversing adverse changes in CV function;
• the integrative (systemic to molecular) biological mechanisms that mediate CV changes with age and disease and the effects of modulating influences and interventions on those changes.
• determine the effects of acute CV responses to a stroke on stroke outcome; and identify approaches to improve stroke outcome in both human and animal models.

 

I operate both human and basic science labs that allow my research questions to be translated from the bench to clinical human studies. We employ a wide range of contemporary experimental techniques to study our research questions in human subjects, rodent models, and cell culture.

 

Current research projects:

1. My recent work (funded with WVU Stroke NIH COBRE) was to determine the physiological and molecular mechanisms that predispose MetS to a worse ischemic stroke on stroke outcome. This project has both a human and animal arm. Our analogous studies in humans and rodents provide an optimal opportunity to dissect pathophysiological mechanisms that contribute to stroke outcome in patients, which will provide the basis for improved clinical management of stroke.

 

2. My lab is interested in understanding the role of perivascular adipose tissue on aortic and arteriole function, and how CVD disease and exercise affects this interaction.

 

3. Another important research question is, how does daily psychosocial stresses lead to cerebro- and peripheral vascular dysfunction, and the mechanisms by which such vascular dysfunction occurs? Does the presence of existing CVD accentuate the vascular dysfunction with daily psychosocial stresses? And can exercise training mitigated the vascular dysfunction? We are working hard to answer such questions. 

 

Grants and Contracts (PI unless otherwise stated)

 

Current Grants and Contracts

WV CTSI Pilot Grant Program ($50,000), PI Chantler,                                                 2017-current

 

Previously Funded Grants and Contracts

NIH, West Virginia Stroke CoBRE (P20 GM109098); PI Simpkins,                             2014- 2017

Project PI: Chantler, ($1,000,000)                                                                                   

 

WV CTSI Pilot Grant Program ($50,000), PI Chantler,                                                 2014-2016

 

CereDx “Stroke Biomaker” project ($11,234.99)                                                           2016-2017

 

Claude Benedum Foundation “Building HOPE in West Virginia”                                  2014-2015

Project PI: Chantler             ($40,000),                                                                            

 

National Swimming Pool Foundation Grant ($50,000), PI Chantler,                            2012-2014

 

AHA Clinical Program Research Grant ($121,000), PI Chantler,                                2011-2013

 

WVU Program to Stimulate Competitive Research ($27,100), PI Chantler,               2012-2013

 

NIH/NHLBI, West Virginia Community Genetics Project (CO-I- 5%)                          2012-2014

 

WVU Research Foundation Development Grant ($22,100), PI Chantler,                  2011-2012

 

  Cardiovascular tools

CV goes here