David P Siderovski, PhD

Professor

Organization:

West Virginia University School of Medicine

Department:

Rockefeller Neuroscience Institute (SOM)

Classification:

Faculty

• PhD, University of Toronto, 1997

• Gross JD, Kaski SW, Schroer AB, Wix KA, Siderovski DP, Setola V (2018). Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants. J Psychopharmacol, 32(2): 191-203. doi: 1177/0269881117742100. PMID: 29364035.
• Gall BJ, Wilson A, Schroer AD, Gross JD, Stoilov P, Setola V, Watkins DM, Siderovski DP. Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance. Genes Immun 2016 [Epub ahead of print].
• Ma P, Ou K, Sinnamon AJ, Jiang H, Siderovski DP, Brass LF. Modulating platelet reactivity through control of RGS18 availability. Blood 2015; 123(24):2611-20.
• Zha Z, Han X, Smith MD, Liu Y, Giguère PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan KL, Lei QY, Xiong Y. A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Mol Cell. 2015; 58(5):794-803.
• Bosch DE, Siderovski DP. Entamoeba histolytica RacC selectively engages p21-activated kinase effectors. Biochemistry 2015; 54(2):404-12.
• Billard MJ, Gall BJ, Richards KL, Siderovski DP, Tarrant TK. G protein signaling modulator-3: a leukocyte regulator of inflammation in health and disease. Am J Clin Exp Immunol 2014; 3(2):97-106.
• Guipponi M, Santoni FA, Setola V, Gehrig C, Rotharmel M, Cuenca M, Guillin O, Dikeos D, Georgantopoulos G, Papadimitriou G, Curtis L, Méary A, Schürhoff F, Jamain S, Avramopoulos D, Leboyer M, Rujescu D, Pulver A, Campion D, Siderovski DP, Antonarakis SE. Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes. PLoS One. 2014; 9(11):e112745.
• Giguère PM, Gall BJ, Ezekwe EA Jr, Laroche G, Buckley BK, Kebaier C, Wilson JE, Ting JP, Siderovski DP, Duncan JA. G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3. J Biol Chem. 2014; 289(48):33245-57.
• Kimple AJ, Garland AL, Cohen SP, Setola V, Willard FS, Zielinski T, Lowery RG, Tarran R, Siderovski DP. RGS21, a regulator of taste and mucociliary clearance? Laryngoscope. 2014; 124(3):E56-63.
• Chen B, Siderovski DP, Neubig RR, Lawson MA, Trejo J. Regulation of Protease-activated Receptor 1 Signaling by the Adaptor Protein Complex 2 and R4 Subfamily of Regulator of G Protein Signaling Proteins. J Biol Chem 2014; 289(3):1580-91.

John J. Abel Award recipient (2004; ASPET)

Wikipedia Page
Personal Page
WVTHDC blog

Personal Site: https://dsiderovski.wordpress.com

Wikipedia page: https://en.wikipedia.org/wiki/David_Siderovski/

Addictions Research Group

Regulators of G protein Signaling (RGS proteins) in health and disease

1. Role of chemokine receptor regulator GPSM3 in rheumatoid arthritis susceptibility
2. Roles of RGS6 and RGS12 in the development of schizophrenic symptomatology
3. Role of RGS12 in satellite cell differentiation and skeletal muscle repair