Xuefang "Sophie" Ren, MD/PhD

Research Assistant Professor; Director, Experimental Stroke Core

Organization:

West Virginia University School of Medicine

Department:

Rockefeller Neuroscience Institute (SOM)

Classification:

Staff

• MD, Ullm University, Germany
• MSc, Immunology, Fudan University, China

[2020]

• Sarvari S, Moakedi F, Hone E, Simpkins JW, Ren X. Mechanisms in blood-brain barrier opening and metabolism-challenged cerebrovascular ischemia with emphasis on ischemic stroke. Metab Brain Dis. 2020 Apr 15. doi: 10.1007/s11011-020-00573-8. [Epub ahead of print] Review. PMID: 32297170
• Hu H, Hone EA, Provencher EAP, Sprowls SA, Farooqi I, Corbin DR, Sarkar SN, Hollander JM, Lockman PR, Simpkins JW, Ren X. MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes. Sci Rep. 2020 Feb 24;10(1):3233. doi: 10.1038/s41598-020-59997-y. PMID: 32094435

[2019]

• Ren X, Engler-Chiurazzi EB, Russell AE, SN Sarkar, SL Rellick, S Lewis, D Corbin, J Clapper, JW Simpkins. (2019). MiR-34a and stroke: Assessment of non-modifiable biological risk factors in cerebral ischemia. Neurochem Int. 2019;127:73–79.
• Farris BY, Monaghan KL, Zheng W, Amend CD, Hu H, Ammer AG, Coad JE, Ren X, Wan ECK. (2019). Ischemic stroke alters immune cell niche and chemokine profile in mice independent of spontaneous bacterial infection. Immun Inflamm Dis. 2019 Dec;7(4):326-341.

[2018]

• Hone EA, Hu H, Sprowls SA, Farooqi I, Grasmick K, Lockman PR, Simpkins JW, Ren X. (2018) Biphasic Blood-Brain Barrier Openings after Stroke. Neurological Disorders and Stroke International 1(2): 1011
• Quintana DD, Ren X, Hu H, Engler-Chiurazzi EB, Rellick SL, Lewis SE, Povroznik JM, Simpkins JW, Alvi M. (2018) Gradual common carotid artery occlusion as a novel model for cerebrovascular Hypoperfusion. Metab Brain Dis. 33(6):2039-2044
• Xuefang Ren, Elizabeth B. Engler-Chiurazzi, Saumyendra N. Sarkar, Stephanie L. Rellick, Sara Lewis, Deborah Corbin, Jarred Clapper, and James W. Simpkins. (2018) MiR-34a and stroke: Assessment of non-modifiable biological risk factors in cerebral ischemia. Neurochem Int.
• Grasmick KA, Hu H, Hone EA, Farooqi I, Rellick SL, Simpkins JW, Ren X. (2018). Uncoupling of the Electron Transport Chain Compromises Mitochondrial Oxidative Phosphorylation and Exacerbates Stroke Outcomes. J Neuroinfect Dis. 2018;9(4):283.
   

[2016]

• Rellick SL, Hu H, Simpkins JW, Ren X* (2016). Evaluation of bioenergetic function in cerebral vascular endothelial cells. J Vis Exp, (117):54847. *Corresponding author.
• Ren X, Simpkins JW. (2016) Advances in our knowledge of stroke mechanisms and therapy. Dana Foundation, Progress in Brain Research, online published
• Sun J, Ren X, Qi W, Yuan D, Simpkins JW (2016). Geissoschizine methyl ether protects oxidative stress-mediated cytotoxicity in neurons through the 'Neuronal Warburg Effect.' J Ethnopharmacol, 187:249-58.
• Engler-Chiurazzi, Stapleton PA, Stalnaker JJ, Ren X, Hu H, Nurkiewicz TR, McBride CR, Yi J, Engels K, Simpkins JW (2016). Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition. J Toxicol Environ Health A, 79(11):447-52.
• Sun J, Hu H, Ren X, Simpkins JW (2016). Tert-butylhydroquinone compromises survival in murine experimental stroke. Neurotoxicol Teratol, 54:15-21.

[2015]

• Ren X, Simpkins JW (2015). Deciphering the blood-brain barrier damage in stroke: mitochondrial mechanism. J Neuroinfect Dis, 6(Suppl 2). pii: e002.
• Doll DN, Hu H, Sun J, Lewis, SE, Simpkins JW, Ren X* (2015). Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier.Stroke, 46(6):1681-1689. *Corresponding author.
• Doll DN, Rellick SL, Barr TL, Ren X, Simpkins JW (2015). Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity. J Neurochem, 32(4):443-51.
• Cui L, Duchamp NS, Boston DJ, Ren X, Zhang X, Hu H, Zhao LR (2015). NF-κB is involved in brain repair by stem cell factor and granulocyte-colony stimulating factor in chronic stroke. Exp Neurol, 263:17-27.

[2012]

• Ren X, Akiyoshi K, Grafe MR, Vandenbark AA, Hurn PD, Herson PS, Offner H (2012). Myelin specific cells infiltrate MCAO lesions and exacerbate stroke severity. Metab Brain Dis, 27(1):7-15.

[2011]

• Ren X, Akiyoshi K, Vandenbark AA, Hurn PD, Offner H (2011). Programmed death-1 pathway limits central nervous system inflammation and neurologic deficits in murine experimental stroke. Stroke, 42(9):2578-2583.
• Ren X, Akiyoshi K, Dzienni S, Vandenbark AA, Herson PS, Hurn PD, Offner H (2011). Regulatory B-cells limit CNS inflammation and neurologic deficits in murine experimental stroke. J Neurosci, 31(23):8556-8563.
• Ren X, Vandenbark AA, Offner H, Herson PS, Hurn PD (2011). Recombinant T cell receptor ligands improve outcome after experimental cerebral ischemia Transl Stroke Res, 2:404-410.
• Dziennis S, Mader S, Akiyoshi K, Ren X, Ayala P, Burrows GG, Vandenbark AA, Herson PS, Hurn PD, Offner H (2011). Therapy with Recombinant T cell Receptor Ligand reduces infarct size and infiltrating inflammatory cells in brain after middle cerebral artery occlusion in mice Metab Brain Dis, 26(2):123:133.
• Ren X, Akiyoshi K, Vandenbark AA, Hurn PD, Offner H (2011).CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke. Metab Brain Dis, 26(1):87-90.

Neuroscience

1. Stroke and Immunology
2. Stroke and mitochondria
3. Stroke and micoRNAs
4. Brain repair and functional recovery after stroke