Mohammed A Nayeem

Professor

Organization:

West Virginia University School of Pharmacy

Department:

Pharmaceutical Sciences

Classification:

Faculty

Adenosine A1 receptors link to smooth muscle contraction via CYP4a, protein kinase C-α, and ERK1/2.
Kunduri SS, Mustafa SJ, Ponnoth DS, Dick GM, Nayeem MA.  J Cardiovasc Pharmacol. 2013 Jul;62(1):78-83. doi: 10.1097/FJC.0b013e3182919591. PMID:  23519140

Mohammed Nayeem, MSc, PhD., is an Assistant Professor in the Department of Pharmaceutical Sciences at West Virginia University, School of Pharmacy. Dr. Nayeem is serving as mentor and co-mentor to PhD. students, Postdoctoral Fellows, undergraduate students and lab technicians. Dr. Nayeem is the Principal Investigator (PI) in a currently funded NHLBI R01 grant (R01HL114559) entitled “Role of Cyp2j-epoxygenases, sEH and PPARs in adenosine-induced vascular response”. He was also a Co-Investigator in funded another NHLBI R01 grant (R01HL094447) entitled “Role of CYP P450s in the Regulation of Vascular Tone through Adenosine Receptors”. Further, he got scored as a Principal Investigator (PI) in another NHLBI Supplemental R01 grant (R01HL114559-03S1) entitled “Angiotensin II and the role of adenosine receptors, epoxygenases, sEH and PPARs with aging” (pending). Dr. Nayeem’s laboratory investigates the mechanism of vascular regulation involves hypertension, salt-sensitive hypertension and coronary reactive hyperemia in adult and aging mice using regular diet /special diet (low salt & high salt) in A_2A AR-null, sEH-null, Tie-2-cyp2j2 Tr, Tie-2-sEH Tr and their respective wild-type mice. Dr. Nayeem’s long-term goal is to identify and develop novel pharmacological agents to target in preventing the progression of prehypertension to hypertension in humans who have allelic variants (genetic polymorphism) that may act similarly to our transgenic (A_2A AR-null, sEH-null, Tie-2-cyp2j2 Tr, Tie-2-sEH Tr) mice in the regulation of vascular tone and blood pressure.

The identification of these signaling pathways will help to unravel the potential mechanism involving arachidonic acid and adenosine receptors in the vascular regulation of hypertension, salt-sensitive hypertension and coronary reactive hyperemia. Dr. Nayeem’s laboratory is one of the very few laboratories that have established a correlation between CYP450s, soluble epoxide hydrolase activities and adenosine receptors signaling. His laboratory is well prepared to undertake the proposed research, because his multidisciplinary research team has expertise as well as unique access to adenosine receptors, cyp-epoxygenases, soluble epoxide hydrolase, PPARα, PPARγ antibodies and specific soluble epoxide hydrolase inhibitor; A_2A AR-null, sEH-null, Tie-2-cyp2j2 Tr, Tie-2-sEH Tr and their respective wild-type mice. Dr. Nayeem has been working in cardiovascular physiology & pharmacology, particularly in the field of Cyp450s and adenosine receptors for almost twelve years, including his training at NIEHS/NIH. He published many papers in peer-reviewed journals and presented work at national and international conferences in the field of cardiovascular Pharmacology.