Dr. Climov is originally from Stefan-Voda, Republic of Moldova. He received his medical degree in Romania and subsequently immigrated to the USA.

Resident

Organization:

West Virginia University School of Medicine

Department:

Surgery

Classification:

Resident

• MD, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Publications: https://www.ncbi.nlm.nih.gov/myncbi/1ZkRT6pI5fnk-/bibliography/public/

Reviewer activity:  https://publons.com/author/1245687/mihail-climov-md#profile

Research investigations:

• Zamfirescu DG, Owen E, Lascar I, Molitor M, Zegrea I, Popescu M, Bishop GA, Lauer CA, Simionescu M, Climov M, Lanzetta M.Sentinel skin allograft-a reliable marker for monitoring of composite tissue transplant rejection - Transplantation proceedings 2009 Mar;41(2):503-8.

• Climov M, Maciuceanu Zarnescu MB, Stefanescu A, Zamfirescu D, Lascar I. Learning curve in hemifacial transplantation in rats. - Chirurgia (Bucur). 2013 Mar-Apr; 108(2):234-40.

• Lee J, Radhakrishnan H, Wu W, Daneshmand A, Climov M, Ayata C, Boas DA, Quantitative imaging of cerebral blood flow velocity and intracellular motility using dynamic light scattering optical coherence tomography -

• Srinivasan VJ, Mandeville ET, Can A, Blasi F, Climov M, Daneshmand A, Lee JH, Yu E, Radhakrishnan H, Lo EH, Sakadžić S, Eikermann-Haerter K, Ayata C. Multiparametric, Longitudinal Optical Coherence Tomography Imaging Reveals Acute Injury and Chronic Recovery in Experimental Ischemic Stroke, PLoS One. 2013; 8(8): e71478.

• Eikermann-Haerter K, Arbel-Ornath M, Yalcin N, Yu ES, Kuchibhotla KV, Yuzawa I, Hudry E, Lattarulo CR, Thyssen D, Climov M, Keles F, Belcher AM, Sengul B, Negro A, Rosen I,Arreguin A, Charles AC, Ferrari MD, Van den Maagdenberg AM, Bacskai BJ, Ayata C.Abnormal synaptic Ca2+ and morphology provide a candidate mechanism for migraine – Ann Neurol. 2015 Aug;78(2):193-210

• Srinivasan V, Yu E, Radhakrishnan H, Can A, Climov M, Leahy C, Ayata C, Eikermann-Haerter K.Micro-Heterogeneity of Flow in a Mouse Model of Chronic Cerebral Hypoperfusion Revealed by Longitudinal Doppler Optical Coherence Tomography and Angiography - J Cereb Blood Flow Metab. 2015 Oct;35(10):1552-60

• Climov M, Medeiros E, Farkash EA, Qiao J, Rousseau CF, Dong S, Zawadzka A, Racki WJ, Al-Musa A, Sachs DH, Randolph M, Huang CA, Bollenbach T. Bioengineered self-assembled skin as an alternative to skin grafts - Plast Reconstr Surg Glob Open. 2016 Jun 10;4(6):e731

• Climov M, Bayer L, Moscoso AV, Matsumine H, Orgill DP. The Role of Dermal Matrices in Treating Inflammatory and Diabetic Wounds - Plast Reconstr Surg. 2016 Sep;138(3 Suppl):148S-57S

• Climov M, Matar AJ, Farkash EA, Medeiros E, Qiao J, Harrington E, Gusha A, Al-Musa A, Sachs DH, Randolph MA, Bollenbach TJ, Huang CA. Survival of Allogeneic Self-Assembled Cultured Skin. Transplantation. 2016 Oct;100(10):2071-8

• Matsumine H, Numakura K, Tsunoda S, Wang H, Matsumine R, Climov M, Giatsidis G, Sukhatme VP,Orgill DP. Adipose-derived aldehyde-dehydrogenase-expressing cells promote dermal regenerative potential with collagen-glycosaminoglycan scaffold-Wound Repair Regen. 2017 Jan;25(1):109-119

• Matsumine H, Numakura K, Climov M, Giatsidis G, Orgill D. Facial-nerve regeneration ability of a hybrid artificial nerve conduit containing uncultured adipose-derived stromal vascular fraction - Microsurgery. 2017 Oct;37(7):808-818

• Climov M, Panayi AC, Borah G, Orgill DP. The life-cycles of skin replacement technologies. PLoS ONE 2020 March;15(3):e0229455

Reviews, chapters, monographs and editorials:

• Climov M, Leavitt T, Molnar J, Orgill D. book chapter: ‘Natural Biomaterials in Skin Tissue Engineering’ in Albana et Holmes-Skin Tissue Engineering and Regenerative Medicine, Elsevier Science, 2016

• Climov M, Garofil D, Nistor B, Vinersar B, Bacanu A, Toma D. (2008). Basic Surgical Skills Training for Medical Students – What can be improved? Oral Presentation presented at: 2^nd International Medical Congress for Students and Young Doctors"MedEspera"; Chisinau, MDA.

• Vinersar B, Bacanu Climov M, Dumitrascuta A, Raducanu D, Vlad Basic Surgical Skills Training for medical students in our experience Oral Presentation presented at: 9th International Congress for Medical Students and Young Doctors "Medicalis 2008"; Cluj, ROU.

• Garofil D, Nistor B, Rosca A, Sgarbura O, Vinersar B, Bacanu A, Climov M, Blajut C, Raducanu D. (2008). Prospective Evaluation of Basic Surgical Skills Course for Medical Students Oral Presentation presented at: 24th National Surgery Congress; Bucharest, ROU.

• Vinersar BA, Toma D, Climov M, Blajut C, Vlad M. (2009). Basic Surgical Skills Training For Medical Students - Two Years of Experience Oral Presentation presented at: 6th International Congress for Medical Students and Young Doctors "Congressis 2009"; Iasi, ROU.

• Zamfirescu D, Lascar I, Climov M. (2009). Simultaneous hemiface and vascularized bone marrow transplantation in rats Oral Presentation HUN.

• Zamfirescu D, Lascar I, Climov M, Bularda A, Popoviciu C, Stefanescu A, Lupu A, Simionescu M, Lanzetta MM. (2010) Simultaneous hemiface and vascularized bone marrow transplantation in rats. In British Journal of Surgery. Vol. 97(S4) Pp. S95-S95.

• Zamfirescu D, Lascar I, Zegrea I, Popescu M, Popoviciu C, Climov M, Lanzetta M, (2011) Vascularized bone marrow transplantation: an alternative to conventional cellular bone marrow transplantation, 10^th Meeting of the International Hand and Composite Tissue Allotransplantation Society, Atlanta, GA,

• Climov M, Zamfirescu D, Stefanescu A, Maciuceanu-Zarnescu B, Lascar I. (2011). Learning curve in hemifacial transplantation in rats Oral Presentation presented at: European Plastic Surgery Research Council; Hamburg, DEU.

• Zamfirescu D, Climov M, Bularda A, Zegrea I, Popescu M, Popoviciu M, Lascar I. (2011). Vascularized bone marrow transplantation induce partial tolerance to hemiface Oral Presentation presented at: European Plastic Surgery Research Council; Hamburg, DEU.

• Climov M. (2012). Immunology of skin substitute derived from allogeneic fibroblasts and keratinocytes in MGH-Miniature swine Oral Presentation presented at: Massachusetts General Hospital Transplant Center Seminar; Boston, MA.

• Murphy GF, Duran-Struuck R, Farkash E, Climov M, Leonard D, Cetrulo C, Spitzer T, Sachs DH, Huang CA. (2012). Histological Assessment of Cutaneous Acute Graft-Versus-Host Disease in a Preclinical Swine Model of Hematopoietic Cell Transplantation and Vascularized Skin Flap Tolerance Poster presented 54th American Society of Hematology Meeting; Atlanta, GA.

• Climov M. (2012). Langerhans cells regulate cutaneous injury by licensing CD8 effector cells recruited to the skin, article by Bennet et al. 2011 Oral Presentation presented at: Massachusetts General Hospital Transplant Center Journal Club; Boston, MA.

• Lee J, Wu W, Climov M, Ayata C, Boas DA, (2012) “Dynamic light scattering optical coherence tomography” Annual Celebration of Science at Massachusetts General Hospital, Boston, USA.

• Climov M, Matar AJ, Medeiros E, Qiao J, Farkash EA, Harrington E, Gusha A, Sachs DH, Randolph M, Bollenbach T, Huang CA, (2013) A Novel Tissue Engineered Construct for Wound Treatment and Skin Immunity Research, American Society of Plastic Surgery Meeting, San-Diego, CA, Plastic & Reconstructive Surgery. 132(4S-1):ii.

• Duran-Struuck R, Climov M, Gusha A, Harrington E, Matar AJ, Crepeau RL, Spitzer TR, Sachs DH and Huang CA, (2013) Immune regulation of allogeneic antibody responses, Cutting Edge of Transplantation -American Society of Transplantation, Phoenix, AZ.

• Duran-Struuck R, Climov M, Gusha A, Harrington E, Matar AJ, Crepeau RL, Spitzer TR, Sachs DS, Huang CA, (2013) Immune Modulation of Antibody Responses Induced Through Allogeneic Cell Transplantation, Biology Of Blood And Marrow Transplantation

• Climov M. (2013). A novel skin substitute for wound treatment and skin immunity research Oral Presentation presented at: Massachusetts General Hospital Transplant Center Seminar; Boston, MA.

• Climov M. (2013). The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood, article by Sharpe et al. 2012 Oral Presentation presented at: Massachusetts General Hospital Transplant Center Journal Club; Boston, MA.

• Climov M, Matar AJ, Medeiros E, Qiao J, Farkash EA, Harrington E, Gusha A, Sachs DH, Randolph M, Bollenbach T, Huang CA, (2014) Novel bioengineered skin substitute for wound treatment and skin immunity research, MGH Scientific Advisory Council meeting

• Climov M, Medeiros E, Farkash EA, Qiao J, Rousseau CF, Dong S, Zawadzka A, Racki WJ, Al-Musa A, Sachs DH, Randolph M,Huang CA, Bollenbach T. (2014). Novel bioengineered skin substitute for wound treatment and skin immunity research Poster presented at: Massachusetts General Hospital Scientific Advisory Committee Meeting; Boston, MA.

• Climov M, McNamee L, Ledley F, Orgill DP. (2015). The patterns of success in Skin Engineering Poster presented at: Discover Brigham Poster Seminar; Boston, MA.

• Matsumine H, Numakura M, Giatsidis G, Orgill DP. (2015). Facial nerve regeneration with uncultured subcutaneous adipose-derived stromal-vascular-fraction in rat model Poster presented Discover Brigham Poster Seminar; Boston, MA.

• Patil A, Climov M, Matar A, Musa A, Harrington E, Sachs D, Duran-Struuck R, Huang C. (2015) B-Cell Tolerance to Donor Alloantigens. Am J Transplant.15 (suppl 3).

• Matsumine H, Numakura M, Giatsidis G, Orgill DP. (2016). Facial nerve regeneration with uncultured subcutaneous adipose-derived stromal-vascular-fraction in rat model Poster presented American Society of Reconstructive Microsurgery, Phoenix, AZ

• Climov M, McNamee L, Ledley F, Orgill DP. (2016). The patterns of success in Skin Engineering Poster presented at: Harvard Surgery Research Day; Boston, MA.

• Christian Schuetz, Mihail Climov, Aarti R. Patil, Zhaohui Wang, Alec Andrews Roy, Nalu Navarro-Alvarez, Abraham j Matar, David H Sachs, Raimon Duran-Struuck, Christene A Huang. (2018). Specific Immunomodulation of Alloantibody Responses, Transplantation, July 2018, Volume 102, Number 7S

• Climov M, Panayi AC, Borah G, Orgill DP. (2018). The evolutionary life-cycles in Skin Replacement Technologies, poster presentation March 2018, Van Lierre, West Virginia University, Morgantown, WV

• Climov M, Panayi AC, Borah G, Orgill DP. (2018). The evolutionary life-cycles in Skin Replacement Technologies, poster presentation, Ohio Valley Society of Plastic Surgery, June 2019

• Climov M, Panayi AC, Borah G, Orgill DP. (2018). The evolutionary life-cycles in Skin Replacement Technologies, oral presentation on Sept 28, 2018, American Society of Plastic Surgery, The Meeting

• Climov M, Liu Y, Guo S, Wei S, Wang H, Liu Y, Moscoso AV, Ribkovskaia Z, Lazarova T, Riesinger S, Orgill DP.  A novel nitric oxide delivery system for diabetic wounds, Van Lierre, March 2019, Morgantown, WV

• Climov M, Liu Y, Guo S, Wei S, Wang H, Liu Y, Moscoso AV, Ribkovskaia Z, Lazarova T, Riesinger S, Orgill DP.  A novel nitric oxide delivery system for diabetic wounds, Ohio Valley Society of Plastic Surgery, May 2019

• McCuloch IL, Mullens CL, Climov M, Jrebi NY, Dumasius VG, Successful Implementation of a "No Sitting" Protocol following V-Y Fasciocutaneous Flap Closure of Abdominoperineal Resections, Ohio Valley Society of Plastic Surgery, May 2019

• Climov M, Liu Y, Guo S, Wei S, Wang H, Liu Y, Moscoso AV, Ribkovskaia Z, Lazarova T, Riesinger S, Orgill DP.  A novel nitric oxide delivery system for diabetic wounds, American Society of Plastic Surgery, The Meeting, San Diego, CA, Sept 2019

• Aldabek K, McCulloch IL, Mullens CL, Climov M, Dumasius V, Jrebi N. Single Center Outcomes of Immediate Internal Pudendal Artery Perforator Flap for Reconstruction for Abdominoperineal Resection Defects, American Society of Colon and Rectal Surgeons (ASCRS), accepted as ePoster presentation at Annual Scientific Meeting in Boston, MA, June 6 – 10, 2020, meeting cancelled due to COVID 19

• Innovation Discovery Recognition, Partners Healthcare for Commitment to Innovation (2016)

• Young Innovator Award, Cutting Edge of Transplantation, American Society of Transplantation (2013)

• Special Prize for paper-presentation, co-author, Congressis 2009, International Congress for Medical Students and Young Doctors (2009)

• Special Prize for paper-presentation, co-author, Medicalis 2008, International Congress for Medical Students and Young Doctors (2008)

• First prize for best oral presentation, MedEspera, International Medical Congress (2008)

Medical School:

Medical School: Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Medical School Graduation Thesis: Facial Transplantation in Rats

Research Fellowships:
- Neurobiology: Stroke and Neurovascular Regulation Laboratory,  Harvard Medical School, 2010-2011,
- Transplant Biology: Transplantation Biology Research Center, T 32 Training Grant, Harvard Medical School, 2011-2014
- Plastic Surgery: Tissue Engineering and Wound Healing Laboratory, Harvard Medical School, 2014-2016

Other: Instructor in Surgery, Harvard Medical School, 2016-2017

Residency: 2017 - present, Integrated Plastic Surgery, WVU

Professional Societies/Leadership Positions:

2006-2009, Romanian Students' Surgical Society, member

2007-2008, Romanian Students' Surgical Society, Treasurer

2008-2009, Romanian Students' Surgical Society, Vice-President

2012-2013, American Association of Immunologists, Member

2013-2014, American Society of Transplantation  , Member

2016- The Society of Brigham Surgical Alumni, Member

2019- present, American Medical Association, Member

2017- present, American Society of Plastic Surgeon, Resident member

2017- present, American Aesthetic Society, Resident member

Personal Interests:

In his leisure time Dr. Climov enjoys spending time with his family and participating in outdoors activities like hiking, fishing, target shooting, and snowboarding. He also likes good food, watching movies, and travelling.