Amanda G Ammer, PhD

Research Assistant Professor

Organization:

West Virginia University School of Medicine

Department:

Microbiology, Immunology & Cell Biology

Classification:

Faculty

Research Assistant Professor

Organization:

West Virginia University WVU Cancer Institute

Department:

WVU Cancer Institute Research Laboratories

Classification:

Staff

Cortactin phosphorylation by casein kinase 2 regulates actin-related protein 2/3 complex activity, invadopodia function and tumor cell invasion.
Markwell SM, Gatesman Ammer AG, Interval ET, Allen JL, Papenberg BW, Hames RA, Castano JE, Schafer DA, Weed SA.
Mol Cancer Res. 2019; 17(4): 987-1001.
PMC6445698

The NAC family transcription factor GmNAC42-1 regulates biosynthesis of the anticancer and neuroprotective glyceollins in soybean.
Jahan MA, Harris B, Lowery M, Coburn K, Infante AM, Percifield RJ, Ammer AG, Kovinich N.
BMC Genomics. 2019; 20(1): 149.
PMC6381636

Altering calcium influx for selective destruction of breast tumor.
Yu HG, McLaughlin SL, Newman M, Brundage KM, Ammer AG, Martin KH, Coad JE.
BMC Cancer. 2017; 17(1): 169.
PMC5336649

Permeability across a novel microfluidic blood-tumor barrier model.
Terrell-Hall TB, Ammer AG, Griffith JIG, Lockman PR.
Fluids Barriers CNS. 2017; 14(1): 3.
PMC5260004

Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer.
Farrugia MK, Sharma SB, Lin CC, McLaughlin SL, Vanderbilt DB, Ammer AG, Salkeni MA, Stoilov P, Agazie YM, Creighton CJ, Ruppert JM.
Cell Death Dis. 2015; 6: e1699.
PMC4385942

Induction of stem-like cells with fibrogenic properties by carbon nanotubes and its role in fibrogenesis.
Luanpitpong S, Wang LY, Manke A, Castranova V, Yang Y, Martin KH, Ammer AG, Rojanasakul Y.
Nano Lett. 2014; 14(6): 3110-3116.
PMC4055043

Ableson kinases negatively regulate invadopodia function and invasion in head and neck squamous cell carcinoma by inhibiting an HB-EGF autocrine loop.
Hayes KE, Walk EL, Ammer AG, Kelley LC, Martin KH, Weed SA.
Oncogene. 2013; 32(40): 4766-4777.
PMC3896120

Quantitative measurement of invadopodia-mediated extracellular matrix proteolysis in single and multicellular contexts.
Martin KH, Hayes KE, Walk EL, Ammer AG, Markwell SM, Weed SA.
J Vis Exp. 2012; (66): 4419.
PMC3606055

Src binds cortactin through a SH2 domain cystine-mediated linkage.
Evans JV, Ammer AG, Jett JE, Bolcato CA, Breaux JC, Martin KH, Culp M, Gannett PM, Weed SA.
J Cell Sci. 2012; 125(Pt 24): 6185-6197.
PMC3585525

Revisiting the ERK/Src cortactin switch.
Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.
Commun Integr Biol. 2011; 4(2): 205-207.
PMC3104580

Further insights into cortactin conformational regulation.
Evans JV, Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.
Bioarchitecture. 2011; 1(1): 21-23.
PMC3158636

Multi-photon imaging of tumor cell invasion in an orthotopic mouse model of oral squamous cell carcinoma.
Ammer AG, Hayes KE, Martin KH, Zhang L, Spirou GA, Weed SA.
J Vis Exp. 2011; (53).
PMC3196194

Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence.
Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.
PLoS One. 2010; 5(11): e13847.
PMC2973953

Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation.
Kelley LC, Ammer AG, Hayes KE, Martin KH, Machida K, Jia L, Mayer BJ, Weed SA.
J Cell Sci. 2010; 123(pt22): 3923-3932.
PMC2972274

Saracatinib impairs head and neck squamous cell carcinoma invasion by disrupting invadopodia function.
Ammer AG, Kelley LC, Hayes KE, Evans JV, Lopez-Skinner LA, Martin KH, Frederick BA, Rothschild BL, Raben D, Elvin P, Green TP, Weed SA.
J Cancer Sci Ther. 2009; 1(2): 52-61.
PMC2875552

Cortactin branches out: roles in regulating protrusive actin dynamics.
Ammer AG, Weed SA.
Cell Motil Cytoskeleton. 2008; 65(9): 687-707.
PMC2561250

PI3K activation is required for PMA-directed activation of cSrc by AFAP-110.
Walker VG, Ammer AG, Cao Z, Clump AC, Jiang BH, Kelley LC, Weed SA, Zot HM, Flynn DC.
Am J Physiol Cell Physiol. 2007; 293(1): C119-C132.

Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification.
Rothschild BL, Shim AH, Ammer AG, Kelley LC, Irby KB, Head JA, Chen L, Varella-Garcia M, Sacks PG, Frederick BA, Raben D, Weed SA.
Cancer Res. 2006; 66(16): 8017-8025.

Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity.
Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi IH, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC.
J Cell Biochem. 2004; 91(3): 602-620.

Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110.
Gatesman AS, Walker VG, Baisden JM, Weed SA, Flynn DC.
Mol Cell Biol. 2004; 24(17): 7578-7597.
PMC506973

Specificity in signaling by c-Yes.
Summy JM, Sudol M, Eck MJ, Monteiro AN, Gatesman AS, Flynn DC.
Front Biosci. 2003; 8: s185-s205.

The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src.
Summy JM, Qian Y, Jiang BH, Guappone-Koay A, Gatesman AS, Shi XL, Flynn DC.
J Cell Sci. 2003; 116(Pt 12): 2585-2598.

The effects of phosphorylation on adaptor protein function.
Cherezova L, Gatesman AS, Flynn DC.
Front Biosci. 2002; 7: d164-d203.

The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases.
Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC.
Oncogene. 2001; 20(45): 6607-6616.