David Klinke, PhD

Adjunct Associate Professor

Organization:

West Virginia University School of Medicine

Department:

Microbiology, Immunology & Cell Biology

Classification:

Adjunct Faculty

Member

Organization:

West Virginia University WVU Cancer Institute

Department:

WVU Cancer Institute Research Programs

Classification:

Adjunct Faculty

• PhD, Northwestern University, 1998

Ten Most Recent:
Melanoma exosomes deliver a complex biological payload that upregulates PTPN11 to suppress T lymphocyte function.
Wu Y, Deng WT, McGinley EC, Klinke DJ.
Pigment Cell Melanoma Res. 2016.

Inferring the impact of regulatory mechanisms that underpin CD8+ T cell control of B16 tumor growth in vivo using mechanistic models and simulation.
Klinke DJ, Wang Q.
Front Pharmacol. 2016; 7: 515.
PMC5209634

Eavesdropping on altered cell-to-cell signaling in cancer by secretome profiling.
Klinke DJ.
Mol Cell Oncol. 2016; 3(1): e1029061.
PMC4845177

Identifying causal networks linking cancer processes and anti-tumor immunity using Bayesian network inference and metagene constructs.
Kaiser JL, Bland CL, Klinke DJ.
Biotechnol Prog. 2016; 32(2): 470-479.
PMC5289651

Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers.
Wu YT, Deng WT, Klinke DJ.
Analyst. 2015; 140(19): 6631-6642.
PMC4986832

CD8 (+) T cell response to adenovirusvaccination and subsequent suppression of tumor growth: modeling, simulation and analysis.
Wang Q, Klinke DJ, Wang Z.
BMC Syst Biol. 2015; 9: 27.
PMC4458046

Interlocked positive and negative feedback network motifs regulate beta-catenin activity in the adherens junction pathway.
Klinke DJ, Horvath N, Cuppett V, Wu YT, Deng WT, Kanj R.
Mol Cell Biol. 2015; 26(22): 4135-4148.
PMC4710243

In silico model-based inference: an emerging approach for inverse problems in engineering better medicines.
Klinke DJ, Birtwistle MR.
Curr Opin Chem Eng. 2015; 10: 14-24.
PMC4545575

Enhancing the discovery and development of immunotherapies for cancer using quantitative and systems pharmacology: Interleukin-12 as a case study.
Klinke DJ.
J Immunother Cancer. 2015; 3: 27.
PMC4468964

Inferring alterations in cell-to-cell communication in HER2+ breast cancer using secretome profiling of three cell models.
Klinke DJ, Kulkarni YM, Wu YT, Byrne-Hoffman C.
Biotechnol Bioeng. 2014; 111(9): 1853-1863.
PMC4423606
 

Personal Website

Mechanisms of Metastasis & Therapeutic Response Program (MMTR)