Pei

Ming Pei, MD, PhD

Professor

Contact

Send an Email
Phone
304-293-1072
Fax
304-293-7070
Address
PO Box 9196
5406 HSS
Morgantown, WV 26506-9196
Additions & Corrections?

Positions

Professor

Organization:
School of Medicine
Department:
Orthopaedics
Classification:
Faculty

Professor

Organization:
School of Medicine
Classification:
Faculty

Member

Organization:
WVU Cancer Institute
Classification:
Faculty

Education

  • PhD, Beijing Medical University, Beijing, China, 1999
  • MSc, Shanghai Medical University, Shanghai, China, 1996
  • MD, Xuzhou Medical College, Jiangsu, China,, 1991

Publications

92 publications in total since joined WVU Orthopedics in 2005

 

2020 (9)

  1. Lu ZH, Zhou S, Vaida J, Gao GM, Stewart A, Parenti J, Yan LQ, Pei M*. Unfavorable contribution of a tissue-engineering cartilage graft to osteochondral defect repair in young rabbits. Frontiers Cell Dev Biol 2020 doi: 10.3389/fcell.2020.595518 (IF: 5.206)  
  2. Wang YM#, Hu GQ#, Hill RC, Dzieciatkowska M, Hansen KC, Zhang XB*, Yan ZQ*, Pei M*. Matrix reverses immortalization-mediated stem cell fate determination. Biomaterials 2020;265:120387. PMID: 32987274 (IF: 10.273) 
  3. Li TY, Chen S, Pei M*. Contribution of neural crest-derived stem cells and nasal chondrocytes to articular cartilage regeneration. Cell Mol Life Sci 2020 Jun 5. Doi: 10.1007/s00018-020-03567-y. PMID: 32504256 (IF: 7.014)
  4. Wang TL, Hill RC, Dzieciatkowska M, Zhu L, Infante AM, Hu GQ, Hansen KC, Pei M*. Site dependent lineage preference of adipose stem cells. Frontiers Cell Dev Biol 2020 Apr 15;8:237. PMID: 32351957. PMCID: PMC7174673. (IF: 5.206)  
  5. Li JT, Narayanan K, Zhang Y, Hill R, He F, Hansen KC, Pei M*. Role of lineage-specific matrix in stem cell chondrogenesis. Biomaterials 2020 Feb;231:119681. Doi: 10.1016/j.biomaterials.2019.119681. PMID: 31864016. PMCID: PMC6958706.  (IF: 10.273) 
  6. Zhou S, Fu YW, Zhang XB*, Pei M*. Liver kinase B1 fine-tunes lineage commitment of human fetal synovium-derived stem cells. J Orthop Res 2020 Feb;38:258-268. doi: 10-1002/jor.24449. PMID: 31429977 (IF: 3.043)  
  7. Lu ZH, Yan LQ, Pei M*. Commentary on “Surface markers associated with chondrogenic potential of human mesenchymal stromal/stem cells”. F1000Research 2020 Jan 23;9:F1000 Faculty Rev-37. Doi: 10.12688/f1000research.21207.1.eCollection 2020. PMID: 32047607. PMCID: PMC6979467.  
  8. Chen W, Chen X, Chen AC, Shi Q, Pan G, Pei M, Yang H, Liu T*, He F*. Melatonin restores the osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells by preserving SIRT1-mediated intracellular antioxidant properties. Free Radic Biol Med 2020 Jan;146:92-106. doi: 10.1016/j.freeradbiomed.2019.10.412. PMID: 31669348 (IF: 5.657)
  9. Yan J, Chen X, Pu C, Zhao Y, Liu X, Liu T, Pan G, Lin J, Pei M, Yang H, He F*. Synovium stem cell-derived matrix enhances anti-inflammatory properties of rabbit articular chondrocytes via the SIRT1 pathway. Mater Sci Eng C Mater Biol Appl 2020 Jan;106:110286. doi: 10.1016/j.msec.2019.110286. PMID: 31753397 (IF: 4.959) 

2019 (6)

  1. Zhang YJ, Lin J, Zhou XF, Chen X, Chen AC, Pi B*, Pan GQ, Pei M, Yang HL, Liu T*, He F*. Melatonin prevents osteoarthritis-induced cartilage degradation via targeting microRNA-140. Oxid Med Cell Longev 2019 Dec 14;2019:9705929. Doi: 10.1155/2019/9705929. PMID: 31915516. PMCID: PMC6935446 (IF: 4.868)  
  2. Wang YM, Fu YW, Yan ZQ*, Zhang XB*, Pei M*. Impact of fibronectin knockout on proliferation and differentiation of human infrapatellar fat pad-derived stem cells. Front Bioeng Biotechnol 2019 Nov 15;7:321. Doi: 10.3389/fbioe.2019.00321. PMID: 31803729. PMCID: PMC6873900. (IF: 5.122)  
  3. Sun Y, Chen S, Zhang XC*, Pei M*. Significance of cellular cross-talk in stromal vascular fraction of adipose tissue in neovascularization. Arterioscler Thromb Vasc Biol 2019 Jun;39:1034-1044. PMID: 31018663. PMCID: PMC6531320 (IF: 6.618)
  4. Li XL, Chen S, Yan LQ, Wang JC*, Pei M*. Prospective application of stem cells to prevent post-operative skeletal fibrosis. J Orthop Res 2019 Jun;37:1236-1245. doi: 10.1002/jor.24266. PMID: 30835890 (IF: 3.043) (invited review)
  5. Zhou S, Chen S, Jiang Q, Pei M*. Determinants of stem cell lineage differentiation toward chondrogenesis versus adipogenesis. Cell Mol Life Sci 2019 May;76:1653-1680. PMID: 30689010. PMCID: PMC6456412. (IF: 7.014) (feature article highlighted in the Subject in Mesenchymal Cell News 11.03 January 29, 2019)
  6. Wang YM, Chen S, Yan ZQ, Pei M*. A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration. Cell Biosci 2019 Jan;9:7. Doi: 10.1186/s13578-018-0264-9. PMID: 30627420. PMCID: PMC6321683 (IF: 3.219)

2018 (9)

  1. Sun Y, Chen S, Pei M*. Comparative advantages of infrapatellar fat pad: an emerging stem cell source for regeneration medicine. Rheumatology 2018 Dec;57:2072-2086. Doi: 10.1093/rheumatology/kex487. PMID: 29373763. PMCID: PMC6256334 (IF: 4.818)
  2. Chen X, Yan JK, He F, Zhong DY, Yang HL, Pei M, Luo ZP. Mechanical stretch induces antioxidant responses and osteogenic differentiation in human mesenchymal stem cells through activation of the AMPK-SIRT1 signaling pathway. Free Radic Biol Med 2018 Oct; 126:187-201. PMID: 30096433. PMCID: PMC6165675 (IF: 6.02)
  3. Pizzute T, He F, Zhang XB*, Pei M*. Impact of Wnt signals on human intervertebral disc cell rejuvenation. J Orthop Res 2018 Dec;36:3196-3207. doi: 10.1002/jor.24115. PMID: 30035326. PMCID: PMC7261601 (IF: 3.414) (featured article in JOR Official Website）
  4. Wang YF, Chen GD, Yan JK, Xhen X, He F, Zhu CH, Zhang JX, Lin J, Pan GQ, Yu J, Pei M, Yang HL, Liu T. Upregulation of SIRT1 by kartogenin enhances antioxidant functions and promotes osteogenesis in human mesenchymal stem cells. Oxid Med Cell Longev 2018 Jul;2018:1368142. PMID: 30116472. PMCID: PMC6079379 (IF: 4.936)
  5. Sun Y, Yan LQ, Chen S, Pei M*. Functionality of decellularized matrix in cartilage regeneration: a comparison of tissue versus cell sources. Acta Biomaterials 2018 Jul;74:56-73. Doi: 10.1016/j.actbio.2018.04.048. PMID: 29702288 (IF: 6.383)
  6. Li M, Chen X, Yan J, Zhou L, Wang Y, He F, Lin J, Zhu C, Pan G, Yu J, Pei M, Yang H, Liu T. Inhibition of osteoclastogenesis by stem cell-derived extracellular matrix through modulation of intracellular reactive oxygen species. Acta Biomaterialia 2018 Apr;71:118-131. PMID: 29526830. PMCID: PMC5899936 (IF: 6.383) (feature article in Mesenchymal Cell News 9.10 March 15, 2018)
  7. Li M#, Yan JK#, Chen X, Tam W, Zhou L, Liu T, Pan GQ, Lin J, Yang HL, Pei M, He F*. Spontaneous up-regulation of SIRT1 during osteogenesis contributes to stem cells’ resistance to oxidative stress. J Cell Biochem 2018 Jun;119:4928-4944. PMID: 29380418. PMCID: PMC5916027 (IF: 3.085)
  8. Li JT, Pei M*. A protocol to prepare decellularized stem cell matrix for rejuvenation of cell expansion and cartilage regeneration. Methods Mol Biol 2018;1577:147-154. Doi: 10.1007/7651_2017_27. PMID: 28451995. PMCID: PMC7261600.
  9. Zhou L, Chen X, Liu T, Zhu CH, Si M, Jargstorf J, Li M, Pan GQ, Gong YH, Luo ZP, Yang HL, Pei M, He F*. SIRT-dependent anti-senescence effects of cell-deposited matrix on human umbilical cord mesenchymal stem cells.  J Tissue Eng Reg Med 2018 Feb;12:e1008-e1021. Doi: 10.1002/term.2422. PMID: 28107614 (IF: 4.71)

2017 (7)

  1. Narayanan K*, Mishra S, Singh S, Pei M, Gulyas B, Padmanabhan P. Engineering concepts in stem cell research. Biotechnol J 2017 Dec;12(12). Doi: 10.1002/biot.201700066. PMID: 28901712 (IF: 3.781)
  2. Zhou L#, Chen X#, Yan JK, Li M, Liu T, Zhu CH, Pan GQ, Guo QP, Yang HL, Pei M, He F*. Melatonin at pharmacologic concentrations suppresses osteoclastogenesis via the attenuation of intracellular ROS. Osteoporosis Int 2017 Dec;28:3325-3337. Doi: 10.1007/s00198-017-4127-8. PMID: 28956094 (IF: 3.591)
  3. Sun Y, Wang TL, Toh WS, Pei M*. The role of laminins in cartilaginous tissues: from development to regeneration. Eur Cell Mater 2017 July;34:40-54. Doi: 10.22203/eCM.v034a03. PMID: 28731483 (IF: 4.887) (5-year IF: 5.984) (feature article in Mesenchymal Cell News 8.29 July 27, 2017)
  4. Chen S#, Fu PL#, Wu HS, Pei M*. Meniscus, articular cartilage, and intervertebral disc: a comparable review of cartilage-like tissues in anatomy, development, and function. Cell Tissue Res 2017 Oct;370:53-70. Doi: 10.1007/s00441-017-2613-0. PMID: 28413859. PMCID: PMC5645221 (IF: 2.948)
  5. Wang TL, Zhu L, Pei M*. Insight into skin cell-based osteogenesis: a review. F1000 faculty invited review. F1000Res 2017 Mar;6:291. PMID: 28413622. PMCID: PMC5365226 (IF: n/a)
  6. Chen X, Li M, Yan J, Liu T, Pan GQ, Yang HL, Pei M, He F*. Alcohol induces cellular senescence and impairs osteogenic potential in bone marrow-derived mesenchymal stem cells. Alcohol Alcohol 2017 May;52:289-297. PMID: 28339869. PMCID: PMC5397879 (IF: 2.724)
  7. Pei M*. Environmental preconditioning rejuvenates adult stem cells’ proliferation and chondrogenic potential. Biomaterials 2017 Feb;117:10-23. Doi: 10.1016/j.biomaterials.2016.11.049. PMID: 27923196. PMCID: PMC5177456 (IF: 8.387)

2016 (4)

  1. Pizzute T#, Li JT#, Zhang Y, Pei M*. FGF ligand dependent proliferation and multi-differentiation of synovium-derived stem cells and concomitant adaptation of Wnt/MAPK signals during chondrogenesis. Tissue Eng Part A 2016;22(15-16):1036-46. PMCID: PMC4991611 (IF: 4.448)
  2. Pizzute T#, Zhang Y#, He F, Pei M*. Ascorbate-dependent impact on cell-derived matrix in modulation of stiffness and rejuvenation of infrapatellar fat derived stem cells toward chondrogenesis. Biomed Mater 2016;11:045009. PMCID: PMC5004760 (IF: 3.697) (feature article in Mesenchymal Cell News 8.32 August 16, 2016)
  3. Wang TL, He JG, Zhang Y, Shi WJ, Dong JS, Pei M*, Zhu L*. A selective cell population from dermis strengthens bone regeneration. Stem Cells Translational Medicine 2017;6:306-315. PMCID: PMC5442747 (IF: 5.709)
  4. Liu X, Zhou L, Chen X, Liu T, Pan G, Cui W, Luo ZP, Pei M, Yang HL, Gong Y, He F*. Culturing on decelularized extracellular matrix enhances antioxidative properties of human umbilical cord-derived mesenchymal stem cells. Mater Sci Eng C Mater Biol Appl 2016;61:437-448. PMID: 26838870 (IF: 3.088)

2015 (10)

  1. Zhang Y#, Chen S#, Pei M*. Biomechanical signals guiding stem cell cartilage engineering: from molecular adaption to tissue functionality. Eur Cell Mater 2015;31:59-78. PMID: 26728499 (IF: 4.887) (5-year IF: 5.984)
  2. Luanpitpong S, Li JT, Manke A, Brundage K, Ellis E, Mclanghlin S, Angsutararux P, Chanthra N, Voronkova M, Chen Y, Wang LY, Chanvorachote P, Pei M, Issaragrisil S, Rojanasakul Y. Slug is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma. Oncogene 2015; doi: 10.1038/onc.2015.351. PMID: 26387547 (IF: 8.459)
  3. Li JT, He F, Pei M*. Chondrogenic priming of human fetal synovium-derived stem cells in an adult stem cell matrix microenvironment. Genes & Diseases 2015;2(4):337-346. doi: 10.1016/j.gendis.2015.06.004 (IF: n/a)
  4. Tang XY, Fan LT, Pei M, Zeng L, Ge ZG. Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives. Eur Cell Mater 2015;30:12-27. PMID: 26214287 (IF: 4.887) (5-year IF: 5.984)
  5. Zhang Y, Pizzute T, Li JT, He F, Pei M*. sb203580 preconditioning recharges matrix-expanded human adult stem cells for chondrogenesis in an inflammatory environment – a feasible approach for autologous stem cell based osteoarthritic cartilage repair. Biomaterials 2015;64:88-97. PMID: 26122165. PMCID: PMC4503335. doi: 10.1016/j.biomaterials.2015.06.038. (IF: 8.557) (highlighted in F1000Prime) (highlighted in Atlas of Science) (http://atlasofscience.org/recharged-autologous-stem-cells/)
  6. Zhou L, Chen X, Liu T, Gong YH, Chen SJ, Pan GQ, Cui WG, Luo ZP, Pei M, Yang HL, He F. Melatonin reverses H2O2-induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway. J Pineal Res 2015;59:190-205. doi: 10.1111/jpi.12250. PMID: 25975679. PMCID: PMC4523475 (IF: 9.6)
  7. Pei M*, Li JT, McConda DB, Wen SJ, Clovis NB, Danley ES. A comparison of tissue engineering based repair of calvarial defects using adipose stem cells from normal and osteoporotic rats. Bone 2015;78:1-10. doi: 10.1016/j.bone.2015.04.040. PMID: 25940459. PMCID: PMC4466199 (IF: 4.461) (highlighted in Atlas of Science) (http://atlasofscience.org/is-a-tissue-engineering-approach-effective-for-the-treatment-of-osteoporotic-bone-defects/#more-8538)
  8. Zhang Y, Li JT, Davis ME, Pei M*. Delineation of in vitro chondrogenesis of human synovial stem cells following preconditioning using decellularized matrix. Acta Biomaterialia 2015;20:39-50. doi: 10.1016/j.actbio.2015.04.001. PMID: 25861949. PMCID: PMC4428941 (IF: 6.025) (feature article in Mesenchymal Cell News 6.14 April 16, 2015) (highlighted in Atlas of Science) (http://atlasofscience.org/building-a-matrix-mediated-cell-expansion-system-for-high-quality-cartilage-regeneration/#more-8417)
  9. Chen S, Fu PL, Cong RJ, Wu HS, Pei M*. Strategies to minimize hypertrophy for cartilage regeneration. Genes & Diseases 2015;2:76-95. PMID: 26000333. PMCID: PMC4437543 (invited review) (IF: n/a)
  10. Pizzute T, Lynch K, Pei M*. Impact of tissue-specific stem cells on lineage specific differentiation: a focus on musculoskeletal system. Stem Cell Rev Rep 2015;11:119-32. doi: 10.1007/s12015-014-9546-8. PMID: 25113801 PMCID: PMC4326629 (IF: 4.523)

2014 (13)

  1. Wang X, Li Y, Han R, He C, Wang G, Wang J, Zheng J, Pei M, Wei L. Demineralized Bone Matrix Combined Bone Marrow Mesenchymal Stem Cells, Bone Morphogenetic Protein-2 and Transforming Growth Factor-β3 Gene Promoted Pig Cartilage Defect Repair. PLoS One 2014;9(12):e116061. doi: 10.1371/journal.pone.0116061. PMID: 25545777. PMCID: PMC4278773 // 2015;10:e0125948. Doi: 10.1371/journal.pone.0125948. PMID: 25970169. PMCID: PMC4430216 (IF: 3.534)
  2. Lynch K, Pei M*. Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies. Organogenesis 2014;10:289-98. doi:10.4161/15476278.2014.970089. PMID: 25482504. PMCID:PMC4594597 (Invited Views and Commentary) (IF: 2.596)
  3. Zhang Y, Pizzute T, Pei M*. A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration. Cell Tissue Res 2014;358:633-49. PMID: 25312291. PMCID: PMC4234693 (IF: 3.677)
  4. He F, Liu XZ, Xiong K, Chen SJ, Zhou L, Cui WG, Pan GQ, Luo ZP, Pei M, Gong YH. Extracellular matrix modulates the biological effects of melatonin in mesenchymal stem cells. J Endocrinol 2014;223:167-80. PMID: 25210047 (IF: 3.586)
  5. Jayasuriya CT, Zhou FH, Pei M, Wang Z, Lemme N, Haines P, Chen Q. Matrilin-3 chondrodysplasia mutations cause attenuated chondrogenesis, premature hypertrophy, and aberrant response to TGF-β in chondroprogenitor cells. Int J Mol Sci 2014;15:14555-73. PMID: 25196597. PMCID: PMC4159868 (IF: 2.339)
  6. Toh WS, Foldager CB, Pei M, Hui JH. Advances in mesenchymal stem cell-based strategies for cartilage repair and regeneration. Stem Cell Rev Rep 2014;10:686-96. PMID: 24869958 (IF: 4.523) (highlighted in F1000Prime)
  7. Zhang Y, Pizzute T, Pei M*. Anti-inflammatory strategies in cartilage repair. Tissue Eng Part B 2014;20:655-68. PMID: 24846478. PMCID: PMC4241874 (IF: 4.64) (feature article in Mesenchymal Cell News 5.20 May 29, 2014)
  8. Karnes J, Zhang Y, Pei M*. Cell Therapy for the Creation of Cartilage and Related Clinical Trials. N. S. Templeton. Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. 4th Edition. Taylor & Francis/CRC Press, 2014. pp. 1123-1135. (K16570_C048) https://doi.org/10.1201/b18002 (invited book chapter)
  9. Li JT, Ohliger J, Pei M*. Significance of epigenetic landscape in cartilage regeneration from the Cartilage Development and Pathology Perspective. Stem Cell Dev 2014;23:1178-94. PMID: 24555773. PMCID: PMC4027988 (IF: 4.791) (feature article in Extracellular Matrix News 5.09 March 13, 2014)
  10. Li JT, Campbell D, Bal G, Pei M*. Can arthroscopically harvested synovial stem cells be preferentially sorted using SSEA4 antibody for mesenchymal tissue regeneration? Arthroscopy 2014;30:352-361. PMID: 24581260 (IF: 3.103) (feature article in MDLinx.com) (highlighted in F1000Prime) (feature article in Mesenchymal Cell News 6.11)
  11. Li JT, Hansen K, Zhang Y, Dong CB, Dinu C, Dzieciatkowska M, Pei M*. Rejuvenation of chondrogenic potential by young stem cell microenvironment. Biomaterials 2014;35:642-653. PMID: 24148243 (IF: 7.604)
  12. Li JT, Pei M*. Decellularized stem cell matrix: a novel approach for autologous chondrocyte-based cartilage repair. M.A. Hayat (ed.). Stem Cells and Cancer Stem Cells: Therapeutic applications in disease and injury. Springer Science + Business Media Dordrecht, 2014. Vol 12, pp. 109-115. doi: 10.1007/978-94-017-8032_10 (invited book chapter)
  13. Pei M*, Li JT, Zhang Y, Liu GH, Wei L, Zhang YY. Expansion on matrix deposited by nonchondrogenic urine stem cells strengthens repeated passage bone marrow stromal cells’ chondrogenic capacity. Cell Tissue Res 2014;356:391-403. PMID: 24705582. PMCID: PMC4128485 (IF: 3.677) (feature article in Extracellular Matrix News 5.13 April 10, 2014)

2013 (4)

  1. Shoukry M, Li J, Pei M*. Reconstruction of an in vitro “niche” for the transition from intervertebral disc development to nucleus pulposus regeneration. Stem Cells Dev 2013;22(8):1162-76. PMID: 23259403. PMCID: PMC3613965 (IF: 4.791) (highlighted in journal cover)
  2. Pei M*, He F, Li JT, Tidwell J, Jones A, McDonough EB. Repair of large animal partial-thickness cartilage defects using matrix rejuvenated synovium-derived stem cells. Tissue Eng Part A 2013;19:1144-54. PMID: 23216161. (IF: 4.64)
  3. He F, Pei M*. Extracellular matrix enhances differentiation of adipose stem cells from infrapatellar fat pad toward chondrogenesis. J Tissue Eng Regen Med 2013;7:73-84.  PMID: 22095700. (IF: 3.534)
  4. Pei M*, Zhang Y, Li JT, Chen DQ. Antioxidation of decellularized stem cell matrix promotes human synovium-derived stem cell-based chondrogenesis. Stem Cells Dev 2013;22(6):889-900. PMID: 23092115. PMCID: PMC3585742 (IF: 4.791)

2012 (10)

  1. Campbell DD, Pei M*. Surface markers for chondrogenic determination: A highlight of synovium-derived stem cells. Cells 2012;1:1107-1120. PMID: 24710545. PMCID: PMC3901147 (IF: n/a)
  2. Pei M*. Can synovium-derived stem cells deposit matrix with chondrogenic lineage-specific determinants? J Tissue Sci Eng 2012;3:3. (IF: n/a) (editorial)
  3. Li JT, Jones B, Zhang Y, Vinardell T, Pei M*. Low density expansion rescues human synovium-derived stem cells from replicative senescence. Drug Deliv Transl Res 2012;2(5):363-374.  PMID: 25787175. (IF: n/a)
  4. Wei F, Zhou J, Wei X, Fleming BC, Terek R, Pei M, Chen Q, Liu T, Wei L. Activation of Indian Hedgehog Promotes Chondrocyte Hypertrophy and Upregulation of MMP-13 in Human Osteoarthritic Cartilage. Osteoarthritis Cartilage 2012;20(7):755-63.  PMID: 22469853. (IF: 4.262)
  5. Jones B, Pei M*. Synovium-derived stem cells: a tissue-specific stem cell for cartilage tissue engineering and regeneration. Tissue Eng Part B Rev 2012; 18:301-11. PMID: 22429320 (IF: 4.64) (feature article)
  6. Guan YJ, Chen Q, Yang X, Haines P, Pei M, Terek R, Wei XC, Zhao T, Wei L. Subcellular Relocation of Histone Deacetylase 4 Regulates Growth Plate Chondrocyte Differentiation through Ca2+/Calmodulin-Dependent Kinase IV. Am J Physiol – Cell Physiol 2012;303:C33-40. PMID: 22442139 PMCID: PMC3404523 (IF: 3.817)
  7. Pei M*, Shoukry M, Li JT, Daffner S, France J, Emery SE. Modulation of in vitro microenvironment facilitates synovium-derived stem cell-based nucleus pulposus tissue regeneration. Spine 2012; 37(18):1538-47. PMID: 22391443. (IF: 2.51)
  8. He F, Pei M*. Rejuvenation of nucleus pulposus cells using extracellular matrix deposited by synovium-derived stem cells. Spine 2012;37(6):459-69. PMID: 21540772 (IF: 2.51)
  9. Li JT, Pei M*. Cell senescence: a challenge in cartilage engineering and regeneration. Tissue Eng Part B 2012;18:270-87.  PMID: 22273114. (IF: 4.64)
  10. Pei M*, He F. Extracellular matrix deposited by synovium-derived stem cells delays chondrocyte dedifferentiation and enhances redifferentiation. J Cell Physiol 2012;227(5):2163-74. PMID: 21792932. PMCID: PMC3265606 (IF: 3.986)

2011 (6)

  1. Pei M*, Li JT, Shoukry M, Zhang Y. A Review of Decellularized Stem Cell Matrix: a Novel Cell Expansion System for Cartilage Tissue Engineering. Eur Cell Mater 2011;22:333-343. PMID: 22116651. (IF: 9.650)
  2. Pei M*, He F, Wei L. Three dimensional cell expansion substrate for cartilage tissue engineering and regeneration: a comparision in decellularized matrix deposited by synovium-derived stem cells and chondrocytes. J Tissue Sci Eng 2011;2:104. doi:10.4172/2157-7552.1000104. (IF: n/a)
  3. Pei M*, He F, Kish VL. Expansion on extracellular matrix deposited by human bone marrow stromal cells facilitates stem cell proliferation and tissue-specific lineage potential. Tissue Eng Part A 2011;17:3067-76. PMID: 21740327. PMCID: PMC3226057 (IF: 4.64)
  4. Li JT, He F, Pei M*. Creation of an in vitro microenvironment to enhance human fetal synovium-derived stem cell chondrogenesis. Cell Tissue Res 2011;345:357-65. PMID: 21805113  (IF: 3.677) (feature article in Extracellular Matrix News)
  5. Li JT, Pei M*. Optimization of an in vitro three-dimensional microenvironment to reprogram synovium-derived stem cells for cartilage tissue engineering. Tissue Eng Part A 2011;17:703-12. PMID: 20929284  (IF: 4.64)
  6. Tidwell J, Pei M*. (2011) Role of Melatonin in Collagen Synthesis. R.R. Watson. Melatonin in the promotion of health. 2nd edition. Florida: Taylor & Francis Group LLC. pp. 471-477. (K11833_C030) (Invited book chapter)

2010 (3)

  1. Tan YB, Zhang YY, Pei M*. Meniscus reconstruction through co-culturing meniscus cells with synovium-derived stem cells on small intestinal submucosa. Tissue Eng Part A 2010;16:67-79. PMID: 19619075. (IF: 4.64)
  2. Wei L, Kanbe K, Lee M, Wei XC, Pei M, Sun XJ, Terek R, Chen Q. Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation. Dev Biol 2010;341:236-45. PMID: 20206617. PMCID: PMC2862458  (IF: 4.094)
  3. Pei M*, Yan ZQ, Shoukry M, Boyce BM. Failure of xenoimplantation using porcine synovium-derived stem cell-based cartilage tissue constructs for the repair of rabbit osteochondral defects. J Orthop Res 2010;28:1064-70. PMID: 20140938  (IF: 2.976) (highlighted in journal cover)

2009 (5)

  1. Pei M*, He F, Boyce BM, Kish VL. Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructs. Osteoarthritis Cartilage 2009;17:714-722. PMID: 19128988 (IF: 4.262)
  2. Chen S, Emery SE, Pei M*. Co-culture of synovium-derived stem cells and nucleus pulposus cells in serum-free defined medium with supplementation of TGF-b1. A potential application of tissue specific stem cells in disc regeneration. Spine 2009; 34:1272-80. PMID: 19455002 (IF: 2.51)
  3. Bilgen B, Ren YX, Pei M, Aaron RK, Ciombor DM. CD14 negative isolation enhances chondrogenesis in synovial fibroblasts. Tissue Eng Part A 2009; 15:3261-70. PMID: 19382853 (IF: 4.64)
  4. Pei M*, Chen DM, Li JT, Wei L. Histone Deacetylase 4 promotes TGF-b1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy differentiation. Differentiation 2009;78:260-8. PMID: 19716643 (IF: 3.311)
  5. He F, Chen XD, Pei M*. Reconstruction of an in vitro tissue-specific microenvironment to rejuvenate synovium-derived stem cells for cartilage tissue engineering. Tissue Eng Part A 2009;15:3809-21. PMID: 19545204. (IF: 4.64)

2008 (4)

  1. Pei M, Luo JM, Chen Q. Enhancing and Maintaining Chondrogenesis of Synovial Fibroblasts by Cartilage Extracellular Matrix Protein Matrilins. Osteoarthritis Cartilage 2008;16:1110-7. PMID: 18282772 (IF: 4.262)
  2. Pei M*, He F, Kish V, Vunjak-Novakovic G. Engineering of Functional Cartilage Tissue Using Stem Cells from Synovial Lining: A Preliminary Study. Clin Orthop Relat Res 2008;466:1880-9. PMID: 18512111 (IF: 2.533)
  3. Pei M*, He F, Vunjak-Novakovic G. Synovium-derived stem cell-based chondrogenesis. Differentiation 2008;76:1044-56. PMID: 18637024 (IF: 3.18)
  4. Pei M*, He F, Rawson A, Wei L. Melatonin enhances chondrogenic differentiation of porcine articular chondrocytes. J Pineal Res 2008;46:181-7. PMID: 19054299 (IF: 7.304)

2007 (1)

  1. Qi LF, Dutta P, Pal S, Seehra M, Pei M*. Morphology Controllable Nanostructured Chitosan Matrix and Its Cytocompatibility. J Biomed Mater Res Part A 2007;87A:236-44. PMID: 18092354 (IF: 2.625)

2005 (1)

  1. Boublik J, Park H, Radisic M, Tognana E, Chen F, Pei M, Vunjak-Novakovic G, Freed LE. Mechanical Properties and Remodeling of Hybrid cardiac Constructs made from heart cells, Fibrin, and Biodegradable, Elastomeric, Knitted Fabric. Tissue Eng 2005;11:1122-32. PMID: 16144448 (IF: 4.64)

Research Program

Alexander B. Osborn Hematopoietic Malignancy and Transplantation

Research Interests

Postdoctoral Research Experience:

  • 1999 – 2002     Postdoctoral Associate, Harvard-MIT Division of Health Sciences and Technology (HST), Massachusetts Institute of Technology (MIT), Cambridge, MA.
  • 2002 – 2005     Research Fellow, Department of Orthopaedics, Brown University, Providence, RI 

Research interests: 

Our lab focuses on tissue regeneration and tissue repair using cutting-edge tissue engineering and stem cell strategies. Currently, our tissues of interest include articular cartilage, bone, intervertebral disc, and meniscus. Engineering a tissue construct is initiated by seeding appropriate cells on biodegradable and biocompatible scaffolds. This step is followed by incubation in an environment with physical and chemical signals (imitating in vivo tissue regeneration and development) to stimulate construct differentiation into premature tissue for implantation. Adult stem cells, such as synovium-derived stem cells (SDSCs), bone marrow derived stem cells (BMSCs), and adipose stem cells (ASCs), have been demonstrated to play a key role in tissue engineering and regeneration. Adult stem cells have proliferation and multilineage differentiation capacities; however, traditional in vitro monolayer culture (2D) makes cells undergo an 'aging' process in which their morphology changes and their proliferative capacity decreases. It is believed that culturing conditions for adult stem cells need to be improved so that adult stem cells can maintain their stemness over time; this is one of the major challenges to be overcome for the advancement of regenerative medicine. Our lab developed a 3D nanostructured expansion system (in vitro stem cell niche) using extracellular matrix (ECM) deposited by adult stem cells. Stem cells expanded on ECM exhibited enhanced proliferation and chondrogenic differentiation capacities. Interestingly, this 3D expansion system also works for primary cells, such as articular chondrocytes and nucleus pulposus cells. Understanding the underlying mechanism and identifying the key component(s) responsible for this rejuvenation effect is important for this technique to be applicable in clinical regenerative medicine. Despite the fact that many mysteries still need to be solved, in vitro reconstruction of the stem cell niche may play a critical role in the next generation of tissue engineering and regenerative medicine.