Benoit Driesschaert, PhD

Assistant Professor

Organization:

West Virginia University School of Pharmacy

Department:

Pharmaceutical Sciences

Classification:

Faculty

Member

Organization:

West Virginia University WVU Cancer Institute

Department:

WVU Cancer Institute Research Programs

Classification:

Faculty

• PhD, University of Louvain, Belgium

 

1.     Dayan N, Ishay Y, Artzi Y, Cristea D, Driesschaert B, Aharon Blank A. Electron spin resonance microfluidics with subnanoliter liquid samples. J Magn Reson. Open 2020; 2-3, 100005.

 

2.     Moore W, McPeak JE, Poncelet M, Driesschaert B, Eaton SS, Eaton GR. 13C isotope enrichment of the central trityl carbon decreases fluid solution electron spin relaxation times. J Magn Reson. 2020;318:106797.

 

3.     Sanzhaeva U, Poncelet M, Tseytlin O, Tseytlin M, Gencheva M, Eubank TD, Khramtsov VV, Driesschaert B*. Synthesis, Characterization, and Application of a Highly Hydrophilic Triarylmethyl Radical for Biomedical EPR. J Org Chem. 2020;85(16):10388-10398.

 

4.     Poncelet M, Driesschaert B*. A 13 C-Labeled Triarylmethyl Radical as an EPR Spin Probe Highly Sensitive to Molecular Tumbling. Angew Chem Int Ed Engl. 2020;10.1002/anie.202006591.

 

5.     Taguchi A , DeVience S , Driesschaert B , Khramtsov VV , Hirata H . In vitro simultaneous mapping of the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance. Analyst. 2020;145(9):3236-3244.

 

6.     Poncelet M, Huffman JL, Khramtsov VV, Dhimitruka I, Driesschaert B*. Synthesis of hydroxyethyl tetrathiatriarylmethyl radicals OX063 and OX071. RSC Adv., 2019,9, 35073-35076

 

7.     Tseytlin O, Guggilapu P, Bobko AA, AlAhmad H, Xu X, Epel B, O'Connell R, Hoblitzell EH, Eubank TD, Khramtsov VV, Driesschaert B, Kazkaz E, Tseytlin M. Modular imaging system: Rapid scan EPR at 800 MHz. J Magn Reson. 2019;305:94-103.

 

8.     Scheinok S, Driesschaert B, d'Hose D, Sonveaux P, Robiette R, Gallez B. Synthesis and characterization of a 5-membered ring cyclic hydroxylamine coupled to triphenylphosphonium to detect mitochondrial superoxide by EPR spectrometry. Free Radic Res. 2019, (11-12):1135-1143

 

9.     Gorodetskii AA, Eubank TD, Driesschaert B, Poncelet M, Ellis E, Khramtsov VV, Bobko AA. Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration. Sci Rep. 2019;9(1):12093

 

10.  Nel J, Desmet CM, Driesschaert B, Saulnier P, Lemaire L, Gallez B. Preparation and evaluation of trityl-loaded lipid nanocapsules as oxygen sensors for electron paramagnetic resonance oximetry. Int J Pharm. 2019;554:87-92.

 

11.  Poncelet M, Driesschaert B*, Tseytlin O, Tseytlin M, Eubank TD, Khramtsov VV. Dextran-conjugated tetrathiatriarylmethyl radicals as biocompatible spin probes for EPR spectroscopy and imaging. Bioorg Med Chem Lett. 2019;29(14):1756-1760.

 

12.  Sanzhaeva U, Xu X, Guggilapu P, Tseytlin M, Khramtsov VV, Driesschaert B*. Imaging of Enzyme Activity by Electron Paramagnetic Resonance: Concept and Experiment Using a Paramagnetic Substrate of Alkaline Phosphatase, Angew. Chem. Int. Ed. 2018;57(36):11701-11705. 
Video abstract: https://vimeo.com/292981331

 

13.  Gorodetskii AA, Eubank TD, Driesschaert B, Poncelet M, Ellis E, Khramtsov VV, Bobko AA. Oxygen-induced leakage of spin polarization in Overhauser-enhanced magnetic resonance imaging: Application for oximetry in tumors, J. Mag. Reson. 2018; 297:42-50.

 

14.  Scheinok S, Leveque P, Sonveaux P, Driesschaert B, Gallez B. Comparison of different methods for measuring the superoxide radical by EPR spectroscopy in buffer, cell lysates and cells. Free Radic Res. 2018; 52(10):1182-1196.

 

15.  Bobko AA, Eubank TD, Driesschaert B, Khramtsov VV. In Vivo Assessment of pH, pO2, Redox Status and Concentrations of Phosphate and Glutathione in Tumor Microenvironment by Electron Paramagnetic Resonance Spectroscopy, J. Vis. Exp. 2018; 133, doi:10.3791/56624.

 

16.  Poncelet M, Driesschaert B*, Bobko AA, Khramtsov VV.  Triarylmethyl based biradical as a superoxide probe, Free Rad. Res. 2018; 52(3):373-379.

 

 

Dr. Driesschaert earned his Ph.D. from the Université Catholique de Louvain (UCL) Belgium. In 2014, he moved to the Ohio State University to carry out his postdoctoral research.  In 2017 Dr. Driesschaert was awarded an NIH K99/R00 Pathway to independence from the NIBIB to launch his independent research programs. He is now an Assistant Professor at the Department of Pharmaceutical Sciences.

Research Interests

• Development of advanced contrast agents for magnetic resonance based imaging (EPR/NMR)
• Nanoformulation and drug delivery system
• Development of fluorescence probes to image reactive oxygen species (ROS)
• Development of polarizing agents for NMR and MRI

Description of Research

Research in my laboratory is focused on the development and applications of probes for medical imaging. Specifically, the lab is developing advanced paramagnetic probes that enable in vivo measurement of physiologically relevant parameters, such as enzyme activities, oxygen concentration or pH non-invasively using magnetic resonance based techniques (EPR/NMR). The development of nanoparticles loaded with an imaging probe and/or a therapeutic agent for diagnostic and/or therapeutic purpose is also an important part of our work. The laboratory develop fluorescence probes that allows for in vivo imaging of reactive oxygen species (ROS). Finaly, we desing and synthesize polarizing agents that allow to enhance the sensititivy of NMR and MRI techniques.